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IP CXCL is an inflammatory chemokine that is produced
2019-09-02
IP-10/CXCL10 is an inflammatory chemokine that is produced by various Y-27632 including leukocytes and acts as a potent chemoattractant for T cells. IP-10 has been reported to create an immune suppressive microenvironment mobilizing immune suppressive cells such as regulatory T cells (Tregs) [25,26
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Our NGS approach on ctDNA was very promising showing a
2019-08-26
Our NGS approach on ctDNA was very promising, showing a high technical success rate (98%), a strong concordance between EGFR sensitizing mutations in tissue samples at diagnosis and in plasma at progression (92%), and a high detection rate of plasma T790 M at progression (71%) with a concordance rat
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We performed a nationwide descriptive observational retrospe
2019-08-16
We performed a nationwide descriptive observational retrospective study. The data were extracted from the French medico-administrative national hospital discharge summary (PMSI for Programme de Médicalisation des Systèmes d’Information) database, gathering discharge abstracts from all hospitals in F
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Introduction Lung cancer is one of the three most common
2019-08-16
Introduction Lung cancer is one of the three most common cancers in England with 37,637 newly diagnosed cases in 2015. It is also the commonest cause of death from cancer with 28,586 deaths annually, representing 21% of all cancer deaths [1]. Although survival rates for lung cancer have been improv
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br Methods br Results br Discussion Compared to
2019-08-16
Methods Results Discussion Compared to clear cell RCC cases within the KPNC study, papillary cases were more likely to be male and African American and less likely to be Hispanic. These findings are consistent with previous studies, including an analysis of 84,255 cases from the SEER Progra
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Cancer fatalism is broadly defined as
2019-08-11
Cancer fatalism is broadly defined as deterministic beliefs about cancer, including the powerlessness of humans to influence cancer outcomes, the definitive role of external causes in the development of cancer, and the inevitability of death after a cancer diagnosis [[51], [52], [53]]. One facet of
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For healthy behavior variables serum median levels of CRP di
2019-08-11
For healthy behavior variables, serum median levels of CRP differed by cigarette smoking status, alcohol drinking status, BMI category, and physical activity level (Table 1). Specifically, with the increase of BMI category from normal weight (BMI Liproxstatin-1 trend of decreasing median CRP levels
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br Discussion We provide a comprehensive analysis on
2019-08-11
Discussion We provide a comprehensive analysis on patterns of care for meningiomas in the United States. This is important in a disease with an increasing incidence and long-term survival [8]. Over 50% of patients were diagnosed by clinical/imaging modalities alone, and 46.7% did not receive init
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9(S)-HODE Mitochondrial transcription factor A TFAM is
2019-07-30
Mitochondrial transcription factor A (TFAM) is essential for mitochondrial transcription and replication [53], [54]. E2 protein could enhance mitochondrial biogenesis by up-regulating TFAM interacting protein P32 or gC1qR [55], [56]. P32/gC1qR, which localizes in the mitochondrial matrix near the nu
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To date several research groups have identified that high
2019-07-30
To-date, several research groups have identified that high lipid levels play a role in the development of cardiomyopathy [27], [28]. In the presence of high plasma concentrations of lipids, including saturated fatty acids (SFA), oxLDL, and cholesterols, the heart is forced to increase lipid uptake [
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The correlation between Na K ATPase activity
2019-07-30
The correlation between (Na++K+)ATPase activity and MMPs has been described in the Dalbavancin [70]. After a prolonged period of ischemia, cardiac tissue shows augmented MMP-2 activity, diminished (Na++K+)ATPase activity, and corresponding protein content changes. It has been shown that Dc protects
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We then explored the cellular and molecular mechanisms under
2019-07-24
We then explored the cellular and molecular mechanisms underlying OPN-orchestrated cardiopathogenesis during the chronic stage of T. cruzi infection. In persistently infected heart displaying exacerbated OPN expression, it is evident that infiltrating CD8+ T BQ-788 sodium salt are one of the princi
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Abnormal and elevated activation of osteoclast formation and
2019-07-24
Abnormal and elevated activation of osteoclast formation and function in breast cancer patients with bone metastasis is one of the major causes of bone osteolysis that impacts the quality of life of the patients [3,28]. Activation of RANK on BMMs by its ligand RANKL, leads to the expression of osteo
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In the liver the chemokine receptor CXCR
2019-07-24
In the liver, the chemokine receptor CXCR6 is predominantly expressed on lymphocytes (NKT, NK, CD4+ and CD8+ T cells), but not on macrophages or neutrophils [5,6]. Its only known ligand CXCL16 is a transmembrane chemokine expressed by liver sinusoidal endothelial Ruxolitinib (INCB018424) [6]. The l
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For decision support in question
2019-07-11
For decision support in question of which model fits best to certain scientific issues, Table 1 summarizes the models by advantages/disadvantages, timelines, species, strain and sex and Table 2 provides a summary of utilities of each animal model presented. Anesthesia regimes recommended for surg