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br We show that IDEA can comprehensively
2019-10-07
We show that IDEA can comprehensively identify several types of genetic alterations with clinical relevance including: single nucleotide variants, insertions and deletions, gene copy number alterations, and rearrangements. To test IDEA in the clinical setting, we exploited an annotated set of samp
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Not only the sensitivity but selectivity is another major fa
2019-10-07
Not only the sensitivity, but selectivity is another major factor for a sensor to be used in bio-imaging. To investigate the selectivity of the CPF nanoprobe towards FA, we have performed the fluorescence re-sponse of the probe toward various potentially coexisting substances, such as Na+, K+, Zn2+,
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br development In this study we identified di erentially
2019-10-07
development. In this study we identified 129 differentially expressed miRNAs, among which five miRNAs are associated with the OS of pa-tients with GC. In addition, the target genes of these five miRNAs were screened, and bioinformatics analysis was used to predict their biolo-gical functions and
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br caption on next page br Fig Rac induced S
2019-10-03
(caption on next page) Fig. 3. Rac1-induced S70 phosphorylation of Bcl-2 is ROS-dependent. (a–b) Western Blot analysis showing S70pBcl-2, Bcl-2, Rac1 and β-actin following 24-h treatment of increasing doses of Tiron in CEM/Bcl-2 and Jurkat cells. n = 4. Bar charts showing fold change in dens
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br Fig Release profiles of DOX from DOX
2019-10-02
Fig. 4. Release profiles of DOX from [email protected]/BSA under different conditions. investigate the influence of reductive agent on DOX release, the Hela Lovastatin were treated with 1 mL DMEM containing 1 mM DTT for 4 h. Here, DTT was chosen as an analog to imitate the concentrated glutathione
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br OshF m and shF m
2019-10-02
3.6. OshF(m) and shF(m) have similar anti-tumor activity, but OshF (m) has a stronger ability to alter the tumor microenvironment To facilitate future clinical research and improve vaccine expres-sion in vivo, we optimized the nucleotide sequence of shF(m) and reduced the sequence homology f
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br The study wide ICER for STOP CRC of
2019-10-01
The study-wide ICER for STOP CRC of $483 per SEP-adjusted completed FIT ($441 in lagged data) is somewhat higher than those of other CRC screening outreach studies (Lewis et al., 2008; Tangka et al., 2013; Liss et al., 2016; Sequist et al., 2010; Meenan et al., 2015). However, each of these studie
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br Lastly given the scarcity of studies
2019-10-01
Lastly, given the scarcity of studies about regulation by miRNAs shared between comprehensive sets of tumor suppressor genes and oncogenes acting on different cell signaling pathways, we investigated whether validated and predicted data sources could identify miRNAs/ miRNA families with potential
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br The availability of more sensitive breast lineage markers
2019-09-26
The availability of more sensitive breast lineage markers that can reliably identify metastatic breast carcinoma that is tri-ple negative for ER, PR, and HER2 would be of high clinical utility. Labeling of TNBC by SOX10 and androgen receptor (AR) has been recently described in primary TNBC. Howeve
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br Statistical analysis of presenting symptoms revealed a si
2019-09-25
Statistical analysis of presenting symptoms revealed a sig-nificant inverse relationship between the frequency of rectal bleeding and the duration of symptoms before referral for colonoscopy, so that patients with rectal bleeding tend to present earlier for colonoscopy than do patients without rec
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br Dehydrated samples were suspended in L of
2019-09-24
Dehydrated samples were suspended in 20 µL of NuPAGE LDS sample buffer (ThermoFisher Scientific). SILAC pairs were mixed, denatured at 90 °C for 2 min and separated on a 10% NuPAGE gel (ThermoFisher Scientific) at 120 V for 20 min. The gel was washed and silver stained (Pierce Silver Stain kit). E
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br Corresponding author at Department of Epidemiology and Bi
2019-09-23
Corresponding author at: Department of Epidemiology and Biostatistics, University of California San Francisco, 2001 Center Street, Suite 700, Berkeley, CA 94704, USA. E-mail address: [email protected] (S. Hurley). the environment. Owing to their highly persistent and bioaccumulative nature
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br The rest of the paper is
2019-09-23
The rest of the paper RGX-104 organized as follows. Section 2 specifies the challenges in the studied data set. In Section 3, the proposed BPCM clustering algorithm is elaborated in detail, including its optimization procedure and a number of favorable properties in missing attribute imputation. S
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br Discussion br Here we identified di
2019-09-23
4. Discussion Here, we identified 335 differentially expressed transcripts that re-flect the degree of genome instability in breast carcinomas. By fitting random forest models, these transcripts were further reduced to 17 genes responsible for the separation between genomically stable and unstab
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br Conclusions br We can
2019-09-23
Conclusions We can conclude that Calcipotriol the increased levels of serum 8-OHdG in patients with BC compared with patients with benign lesions and healthy controls may have a significant effect on BC development and might help as a potential biomarker for assessing individuals with high risk