br Competing financial interests declaration br The author h
Competing financial interests declaration
The author has previously done consulting for EPRI, not related to this work.
No external funding was obtained for this study.
Appendix A. Supporting information
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Analysis of a National Programme for Selective Internal Radiation Therapy for Colorectal Cancer Liver Metastases
z Centre for Health Technology Evaluation, National Institute for Health and Care Excellence, London, UK x Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK Nottingham University Hospitals NHS Trust, Nottingham, UK jj Leeds Teaching Hospitals NHS Trust, St James’s Hospital, Leeds, UK ** Department of Radiology, The Christie NHS Foundation Trust, Manchester, UK yy The Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK zz NHS England, Institute of Oncology, St James’s University Hospital, Leeds, UK
xx The Christie NHS Foundation Trust, Withington, Manchester, UK NIHR University College London Hospitals Biomedical Research Centre, UCL Cancer Institute, University College London, London, UK
Aims: Patients with chemotherapy-refractory colorectal cancer liver metastases have limited therapeutic options. Selective internal radiation therapy (SIRT) delivers yttrium 90 microspheres as a minimally invasive procedure. This prospective, single-arm, observational, service-evaluation study was part of National Health Service England Commissioning through Evaluation.
Methods: Patients eligible for treatment had histologically confirmed carcinoma with liver-only/liver-dominant metastases with clinical progression during or following oxaliplatin-based and irinotecan-based chemotherapy. All patients received SIRT plus standard of care. The primary outcome was overall survival; secondary outcomes included safety, progression-free survival (PFS) and liver-specific PFS (LPFS).